Scar management by means of occlusion and hydration: a comparative study of silicones versus a hydrating gel-cream.
نویسندگان
چکیده
Despite the worldwide use of silicones in scar management, its exact working mechanism based on a balanced occlusion and hydration, is still not completely elucidated. Moreover, it seems peculiar that silicones with completely different occlusive and hydrating properties still could provide a similar therapeutic effect. The objective of the first part of this study was to compare the occlusive and hydrating properties of three fluid silicone gels and a hydrating gel-cream. In a second part of the study these results were compared with those of silicone gel sheets. Tape stripped skin was used as a standardized scar like model on both forearms of 40 healthy volunteers. At specific times, trans epidermal water loss (TEWL) and the hydration state of the stratum corneum were measured and compared with intact skin and a scar-like control over a 3-4h period. Our study clearly demonstrated that fluid silicone gels and a hydrating gel-cream have comparable occlusive and hydrating properties while silicone gel sheets are much more occlusive, reducing TEWL values far below those of normal skin. A well-balanced, hydrating gel-cream can provide the same occlusive and hydrating properties as fluid silicone gels, suggesting that it could eventually replace silicones in scar treatment.
منابع مشابه
Specific gel-cream as adjuvant to oral isotretinoin improved hydration and prevented TEWL increase--a double-blind, randomized, placebo-controlled study.
BACKGROUND Hydrating and emollient products are often recommended to patients under isotretinoin therapy to control the most frequent mucocutaneous side effects and to improve adherence to treatment. AIMS To assess, using noninvasive biophysical tests, the clinical and instrumental effectiveness of a hydrating gel-cream compared with placebo as an adjuvant to isotretinoin for treatment of fac...
متن کاملResveratrol-Loaded Lipid Nanocarriers: Correlation between In Vitro Occlusion Factor and In Vivo Skin Hydrating Effect
Lipid nanocarriers show occlusive properties that may be related to their ability to improve skin hydration. The aim of this work was to evaluate the relationship between in vitro occlusion factor and in vivo skin hydration for three types of lipid nanocarriers: nanoemulsions (NEs), solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs). These lipid nanocarriers were loaded w...
متن کاملThe Influence of Various Silicones on the Rheological Parameters of AZG Containing Silicone-Based Gels
Aluminium zirconium tetrachlorohydrex glycine (AZG) is a popular antiperspirant/deodorant agent, formulated in various forms including the clear gels. Silicones are used for the preparation of these gels, giving them desirable characteristics. The aim of this study was to investigate the influence of various silicones, when used in combination, on the rheological properties of the resulting AZG...
متن کاملThe Influence of Various Silicones on the Rheological Parameters of AZG Containing Silicone-Based Gels
Aluminium zirconium tetrachlorohydrex glycine (AZG) is a popular antiperspirant/deodorant agent, formulated in various forms including the clear gels. Silicones are used for the preparation of these gels, giving them desirable characteristics. The aim of this study was to investigate the influence of various silicones, when used in combination, on the rheological properties of the resulting AZG...
متن کاملFormulation of mefenamic acid loaded transfersomal gel by thin film hydration technique and hand shaking method
Objective(s): The aim of present study is to formulate mefenamic acid transdermal gel based on vesicular drug delivery approaches.Materials and Methods: For the preparation of mefenamic acid transdermal gel, transfersomes were selected as colloidal carriers. Transfersomes were prepared by hand shaking and thin film hydration techniques. The obtained transfersomes were characterized for vesicula...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Burns : journal of the International Society for Burn Injuries
دوره 39 7 شماره
صفحات -
تاریخ انتشار 2013